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Simon is the associate dean for Research and an associate professor in OHIO's College of Health Sciences and Professions. She is an expert in injury epidemiology, retired athletes and aging. The overarching goal of her research program is on the epidemiology and treatment of musculoskeletal impairments due to injury, aging, and metabolic disease. 

Within this scope, she maintains programmatic efforts in two focused areas: 1) epidemiology and treatment of musculoskeletal injuries, and 2) the treatment and long-term patient-reported outcomes of impaired musculoskeletal and physiological function due to advancing age, cancer, substance use, and metabolic disease.