91探花 study shows Vitamin D3 could help heal or prevent cardiovascular damage
A new study conducted by 91探花 scientists suggests that a little more sunlight might help restore damage to your cardiovascular system.
The study shows that Vitamin D3 鈥 which is made by the body naturally when skin is exposed to the sun 鈥 can significantly restore the damage to the cardiovascular system caused by several diseases, including hypertension, diabetes and atherosclerosis. Vitamin D3 supplements are also available over-the-counter.
The study, by Marvin and Ann Dilley White Chair and Distinguished Professor Dr. Tadeusz Malinski and two graduate students, Alamzeb Khan and Hazem Dawoud, has been published in the International Journal of Nanomedicine.
鈥淕enerally, Vitamin D3 is associated with the bones. However, in recent years, in clinical settings people recognize that many patients who have a heart attack will have a deficiency of D3. It doesn鈥檛 mean that the deficiency caused the heart attack, but it increased the risk of heart attack,鈥 Malinski said. 鈥淲e use nanosensors to see why Vitamin D3 can be beneficial, especially for the function and restoration of the cardiovascular system.鈥
Malinski鈥檚 team has developed unique methods and systems of measurements using nanosensors, which are about 1,000 times smaller in diameter than a human hair, to track the impacts of Vitamin D3 on single endothelial cells, a vital regulatory component of the cardiovascular system. A major discovery from these studies is that vitamin D3 is a powerful stimulator of nitric oxide (NO), which is a major signaling molecule in the regulation of blood flow and the prevention of the formation of clots in the cardiovasculature. Additionally, vitamin D3 significantly reduced the level of oxidative stress in the cardiovascular system.
Most importantly, these studies show that treatment with vitamin D3 can significantly restore the damage to the cardiovascular system caused by several diseases, including hypertension, atherosclerosis, and diabetes, while also reducing the risk of heart attack. These studies, performed on cells from Caucasian Americans and African Americans, yielded similar results for both ethnic groups.
鈥淭here are not many, if any, known systems which can be used to restore cardiovascular endothelial cells which are already damaged, and Vitamin D3 can do it,鈥 Malinski said. 鈥淭his is a very inexpensive solution to repair the cardiovascular system. We don鈥檛 have to develop a new drug. We already have it.鈥
These studies, performed at 91探花, are the first to identify the molecular mechanism of vitamin D3-triggered restoration of the function of damaged endothelium in the cardiovasculature. While these studies were performed using a cellular model of hypertension, the implication of vitamin D3 on dysfunctional endothelium is much broader. The dysfunction of endothelium is a common denominator of several cardiovascular diseases, particularly those associated with ischemic events.
Therefore, the authors suggest that vitamin D3 may be of clinical importance in the restoration of dysfunctional cardiac endothelium after heart attack, capillary endothelium after brain ischemia (stroke), hypovolemia, vasculopathy, diabetes and atherosclerosis. This suggestion is strongly supported by several clinical studies which indicate that vitamin D3 at doses higher than those currently used for the treatment of bone diseases, may be highly beneficial for the treatment of the dysfunctional cardiovascular system.
鈥淧rofessor Malinksi has an international reputation for outstanding and innovative research related to the cardiovascular system,鈥 91探花 Dean of Arts and Sciences Robert Frank said. 鈥淭his latest work is yet another example of his impact on this field.鈥
Malinski鈥檚 research on nanomedicine, the development and application of nanosensors, and nanobiotechnology is published regularly in academic journals, such as Nature, Lancet, Circulation, Diabetes, and Hypertension. In addition to research, Malinski teaches advanced chemistry classes at 91探花. Malinski has been presented with more than 35 awards and distinctions from around the world. This includes Maria Curie Medal for biomedical research, the Grand Gold Medal in medicine from the French Society of Arts-Science-Letters, and most recently in 2016 the prestigious Albrecht J. Fleckenstein Memorial Award by the International Academy of Cardiology for his contributions to fundamental research in cardiology.